Understanding and differentiating bipolar I
and bipolar II depression

Bipolar depression is debilitating and
difficult to diagnose1-3

Bipolar disorder is a chronic mental illness that causes dramatic shifts in a person's mood, energy and ability to think clearly.4 Patients with bipolar disorder can experience high and low moods—known as mania and depression. The depressive phases or “lows” of bipolar disorder are often very debilitating and difficult to manage for patients.1

˜

11 million
affected by bipolar
disorder in the US4,5

Prevalence of bipolar disorder
similar for
males and females4

Depressive episodes can be longer & more frequent
than manic/hypomanic episodes6

3X

MORE
LIKELY

for patients with bipolar
disorder to experience
bipolar depression
than mania7

˜90%

of patients report severe
impairment due to
depressive episodes1

Patients often face delays before receiving
appropriate treatment3

May take as long as

10 years

to diagnose
patients with bipolar disorder8

75%

BIPOLAR
PATIENTS

misdiagnosed
with unipolar depression
(major depressive disorder)3

See what factors could lead to a change in diagnosis from
unipolar depression to bipolar depression9-12

Differentiating bipolar I and
bipolar II depression

SIMILAR POPULATION SIZE

FOR BIPOLAR I AND BIPOLAR II PATIENTS1

How to identify and differentiate patients with bipolar I or bipolar II1,6,13-17

How to identify and differentiate patients
with bipolar I or bipolar II1,6,13-17

BIPOLAR I
characterized by ≥1
manic
episode:

  • Lasting ≥1 week
  • Hospitalization
  • Functional
    impairment
  • Psychotic
    symptoms
    (up to 75%)

BIPOLAR I & II
characterized by
depressive episodes:

  • Hospitalization
  • Functional
    impairment
  • Psychotic
    symptoms

BIPOLAR II
characterized by
hypomania, not mania:

  • Lasting ≥4 days
  • No hospitalizations
  • No psychotic
    symptoms
  • No marked
    functional
    impairment

Unlike some medicines that only treat bipolar I, CAPLYTA treats both bipolar I and bipolar II depression in adults20

References: 1. Merikangas KR, Akiskal HS, Angst J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry. 2007;64(5):543-552. 2. Miller S, Dell'Osso B, Ketter TA. The prevalence and burden of bipolar depression. J Affect Disord. 2014;169(S1):S3-S11. 3. Frye MA, Calabrese JR, Reed ML, et al. Use of health care services among persons who screen positive for bipolar disorder. Psychiatr Serv. 2005;56(12):1529-1533. 4. National Institute of Mental Health. Bipolar Disorder. Accessed October 21, 2021. https://www.nimh.nih.gov/health/statistics/bipolar-disorder. 5. United States Census Bureau. State population by characteristics: 2010-2020. October 8, 2021. Accessed December 7, 2021. https://www.census.gov/programs-surveys/popest/technical-documentation/research/evaluation-estimates/2020-evaluation-estimates/2010s-state-detail.html. 6. Baldessarini RJ, Vázquez GH, Tondo L. Bipolar depression: a major unsolved challenge. Int J Bipolar Disord. 2020;8(1):1. 7. Kupka RW, Altshuler LL, Nolen WA, et al. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord. 2007;9:531-535. 8. Swartz HA and Suppes T. Bipolar II Disorder: Recognition, Understanding, and Treatment. American Psychiatric Association Publishing; 2019. 9. Osser DN. Bipolar depression: how not to miss the diagnosis. Psychiatr Times. 2021;38(10). Accessed November 16, 2021. https://www.psychiatrictimes.com/view/bipolar-depression-how-not-to-miss-the-diagnosis. 10. McIntyre RS, Berk M, Brietzke E, et al. Bipolar disorders. Lancet. 2020;396(10265):1841-1856. 11. Bowden CL. A different depression: clinical distinctions between bipolar and unipolar depression. J Affect Disord. 2005;84(2-3):117-125. 12. Bauer M, Pfennig A. Epidemiology of bipolar disorders. Epilepsia. 2005;46(suppl 4):8-13. 13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed Text Revision. American Psychiatric Association; 2022. 14. Carvalho AF, Firth J, Vieta E. Bipolar disorder. N Engl J Med. 2020;383(1):58-66. 15. Hirschfeld RM. Bipolar depression: the real challenge. Eur Neuropsychopharmacol. 2004;14 (suppl 2):S83-S88. 16. Dunayevich E, Keck PE Jr. Prevalence and description of psychotic features in bipolar mania. Curr Psychiatry Rep. 2000;2(4):286-290. 17. Karanti A, Kardell M, Joas E, et al. Characteristics of bipolar I and II disorder: a study of 8766 individuals. Bipolar Disord. 2020;22(4):392-400. 18. Vinberg M et al. Differences in clinical presentation between bipolar I and II disorders in the early stages of bipolar disorder: A naturalistic study. J Affect Disord. 2017;208:521-527. 19. Forte A, Baldessarini RJ, Tondo L et al. Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders. J Affect Disord. 2015;178:71-78. 20. CAPLYTA prescribing information.