For SCHIZOPHRENIA in adultsObserved reductions in PANSS symptom domains in patients on CAPLYTA1
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subscale scores at 4 weeks1
Limitation: These secondary endpoint and exploratory post hoc analyses were not powered for statistical comparison and are descriptive only; results require cautious interpretation.
Baseline PANSS Total Scores: CAPLYTA 42 mg: 88.1; placebo: 86.3.1
LSM=least squares mean; PANSS=Positive and Negative Syndrome Scale.
The PANSS is a 30-item scale that measures the following symptoms1,2,5*:
Positive Subscale Symptoms:
- Delusions
- Hallucinations
- Conceptual disorganization
- Excitement
- Grandiosity
- Suspiciousness/persecution
- Hostility
Negative Subscale Symptoms:
- Blunted affect
- Emotional withdrawal
- Poor rapport
- Passive/apathetic social withdrawal
- Difficulty in abstract thinking
- Lack of spontaneity and flow of conversation
- Stereotyped thinking
General Psychopathology Subscale Symptoms:
- Somatic concern
- Anxiety
- Guilt feelings
- Tension
- Mannerisms and posturing
- Depression
- Motor retardation
- Uncooperativeness
- Unusual thought content
- Disorientation
- Poor attention
- Lack of judgement and insight
- Disturbance of volition
- Poor impulse control
- Preoccupation
- Active social avoidance
PANSS Prosocial Subscale
The PANSS Prosocial Subscale is a 6-item scale derived from the PANSS total score to measure social functioning. It includes the following symptoms:
- Hallucinations
- Suspiciousness/persecution
- Emotional withdrawal
- Passive/apathetic social withdrawal
- Stereotyped thinking
- Active social avoidance
*Each item is rated by a clinician on a 7-point scale. A score of 1 indicates the absence of symptoms, and a score of 7 indicates extremely severe symptoms. The PANSS total score may range from 30 to 210, with higher scores reflecting greater overall symptom severity.2,5
PANSS=Positive and Negative Syndrome Scale.
