Exploratory analysis in adults with MDDChange from baseline average score across individual MADRS items at 6 weeks^1‑3*

Numerical improvement seen across all 10 MADRS items at Week 6

^†Patients were excluded from study enrollment if investigator determined they were at significant risk for suicidal behavior during participation in the study; the patient scored “yes” on Suicidal Ideation Items 4 or 5 of the Columbia-Suicide Severity Rating Scale within 6 months prior to screening or at baseline; the patient scored “yes” on Suicidal Ideation Items 4 or 5 since the screening visit; the patient had 1 or more suicide attempts within 2 years prior to screening; the patient scored ≥5 on MADRS Item 10 (Suicidal Thoughts) at screening or baseline; or the patient was considered to be in imminent danger to him/herself or others.^2,3