Major depressive disorder (MDD) and bipolar depression symptoms can overlap, which could contribute to misdiagnosis¹

In a study of patient-reported survey data*

~4 out of 5 patients screened for bipolar disorder were misdiagnosed, most often with MDD, or undiagnosed²

Symptoms of MDD that can overlap with bipolar depression include^1,3:

Depressed mood

Anhedonia

Anxiety

Change in appetite

Cognitive defects

Suicidal thoughts

*Based on respondents who screened positive for bipolar disorder (n=1167) according to the Mood Disorder Questionnaire.²

See the efficacy of CAPLYTA in adults with bipolar I and II depression

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References: 1. Mitchell PB, Frankland A, Hadzi-Pavlovic D, et al. Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees. Br J Psychiatry. 2011;199(4):303-309. doi:10.1192/bjp.bp.110.088823 2. Frye MA, Calabrese JR, Reed ML, et al. Use of health care services among persons who screen positive for bipolar disorder. Psychiatr Serv. 2005;56(12):1529-1533. doi:10.1176/appi.ps.56.12.1529 3. Kwon SS, Lee H, Lee J, et al. Understanding anxiety symptoms of mood disorders across bipolar and major depressive disorder using network analysis. Medicina (Kaunas). 2025;61(12):2245. doi:10.3390/ medicina61122245

Major depressive disorder (MDD) and bipolar depression symptoms can overlap, which could contribute to misdiagnosis1

~4 out of 5 patients screened for bipolar disorder were misdiagnosed, most often with MDD, or undiagnosed2

Symptoms of MDD that can overlap with bipolar depression include1,3:

Major depressive disorder (MDD) and bipolar depression symptoms can overlap, which could contribute to misdiagnosis¹

~4 out of 5 patients screened for bipolar disorder were misdiagnosed, most often with MDD, or undiagnosed²

Symptoms of MDD that can overlap with bipolar depression include^1,3: