Understanding major depressive disorder in adults

When initial antidepressant treatment falls short, consider an atypical antipsychotic add-on1

2 out of 3 patients on treatment have unresolved symptoms that persist2

These patients may struggle with concerns including3-5:

  • Anxiety
  • Anhedonia
  • Cognitive deficits
  • Guilt
  • Impaired work
  • Irritability
  • Joint pain
  • Metabolic concerns
  • Muscle aches
  • Sexual dysfunction
  • Trouble sleeping
  • Weight issues
Learn more about the efficacy of an add-on for adults with MDD
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References: 1. Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am J Psychiatry. 2010. 2. Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer‑term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–1917. doi:10.1176/ajp.2006.163.11.1905 3. Mago R, Faiolini A, Weiller E, Weiss C. Understanding the emotions of patients with inadequate response to antidepressant treatments: results of an international online survey in patients with major depressive disorder. BMC Psychiatry. 2018;18(1):33. doi:10.1186/s12888-018-1625-y 4. Habert J, Katzman MA, Oluboka OJ, et al. Functional recovery in major depressive disorder: focus on early optimized treatment. Prim Care Companion CNS Disord. 2016;18(5). doi:10.4088/PCC.15r01926 5. Israel JA. The impact of residual symptoms in major depression. Pharmaceuticals (Basel). 2010;3(8):2426‑2440. doi:10.3390/ph3082426

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