Efficacy

Mean scores in PANSS symptom domains were improved in patients treated with CAPLYTA2

Secondary endpoints: Change in PANSS symptom domains in Study 1

Study 1. Change from baseline in positive, negative, and general psychopathology subscale (GPS) symptoms of schizophrenia at 4 weeks2

Limitation: These secondary endpoints were not powered for statistical comparison and are descriptive only. Therefore, the results require cautious interpretation.

Limitation: These secondary endpoints were not powered for statistical comparison and are descriptive only. Therefore, the results require cautious interpretation.

PANSS is a 30-item scale that measures the following symptoms6*:

Positive subscale symptoms
  • Delusions
  • Hallucinations
  • Conceptual disorganization
  • Excitement
  • Grandiosity
  • Suspiciousness/persecution
  • Hostility
Negative subscale symptoms
  • Blunted affect
  • Emotional withdrawal
  • Poor rapport
  • Passive/apathetic social withdrawal
  • Difficulty in abstract thinking
  • Lack of spontaneity and flow of conversation
  • Stereotyped thinking
GPS symptoms
  • Somatic concern
  • Anxiety
  • Guilt feelings
  • Tension
  • Mannerisms and posturing
  • Depression
  • Motor retardation
  • Uncooperativeness
  • Unusual thought content
  • Disorientation
  • Poor attention
  • Lack of judgment and insight
  • Disturbance of volition
  • Poor impulse control
  • Preoccupation
  • Active social avoidance

LSM=least squares mean.

Each item is rated by a clinician on a 7-point scale. A score of 1 indicates the absence of symptoms, and a score of 7 indicates extremely severe symptoms. The PANSS total score may range from 30 to 210, with higher scores reflecting greater overall symptom severity.1